A team of US researchers recently reported the design, assembly and in vivo functionality of a synthetic chromosome III (SynIII) for the yeast Saccharomyces cerevisiae. The synthetic chromosome was assembled bottom‐up from DNA oligomers by teams of students working over several years with researchers as the first part of an international synthetic yeast genome project. Embedded into the sequence of the synthetic chromosome are multiple design changes that include a novel in‐built recombination scheme that can be induced to catalyse intra‐chromosomal (...) rearrangements in a variety of different conditions. This system, along with the other synthetic sequence changes, is intended to aid researchers develop a deeper understanding of how genomes function and find new ways to exploit yeast in future biotechnologies. The landmark of the first synthesised designer eukaryote chromosome, and the power of its massively parallel recombination system, provide new perspectives on the future of synthetic biology and genome research. (shrink)

Marshall and colleagues (2024) offer a framework for emergency physicians (EPs) tasked with caring for “resuscitated opioid users”—or patients who have recently overdosed on opioids. This framework...

Mild and moderate mental illnesses can hinder labor force participation, lead to work interruptions, and hamper earning potential. Targeted interventions have proven effective at addressing these problems. But their potential depends on labor protections that enable people to take advantage of these interventions while keeping jobs and income.

Chance both guides our credences and is an objective feature of the world. How and why we should conform our credences to chance depends on the underlying metaphysical account of what chance is. I use considerations of accuracy (how close your credences come to truth-values) to propose a new way of deferring to chance. The principle I endorse, called the Trust Principle, requires chance to be a good guide to the world, permits modest chances, tells us how to listen to (...) chance even when the chances are modest, and entails but is not entailed by the New Principle. As I show, a rational agent will obey this principle if and only if she expects chance to be at least as accurate as she is on every good way of measuring accuracy. Much of the discussion, and the technical results, extend beyond chance to deference to any kind of expert. Indeed, you will trust someone about a particular question just in case you expect that person to be more accurate than you are about that question. (shrink)

In Plato's Lysis, Socrates' conversation with Lysis features logical fallacies and questionable premises and closes with a blatantly eristic trick. I show how the form and content of these arguments make sense if we interpret them from the perspective of Socrates' pedagogical goals. Lysis is a competitive teenager who, along with his friend Menexenus, enjoys the game of eristic disputation. Socrates recognizes Lysis' predilections, and he constructs his arguments to engage Lysis' interests and loves, while also drawing the boy into (...) thinking philosophically about the issues that the arguments raise about love, freedom, and happiness. (shrink)

Despite their ethical intentions, ethically minded consumers rarely purchase ethical products (Auger and Devinney: 2007, Journal of Business Ethics76, 361–383). This intentions–behaviour gap is important to researchers and industry, yet poorly understood (Belk et al.: 2005, Consumption, Markets and Culture8(3), 275–289). In order to push the understanding of ethical consumption forward, we draw on what is known about the intention–behaviour gap from the social psychology and consumer behaviour literatures and apply these insights to ethical consumerism. We bring together three separate (...) insights – implementation intentions (Gollwitzer: 1999, American Psychologist54(7), 493–503), actual behavioural control (ABC) (Ajzen and Madden: 1986, Journal of Experimental Social Psychology22, 453–474; Sheeran et al.: 2003, Journal of Social Psychology, 42, 393–410) and situational context (SC) (Belk: 1975, Journal of Consumer Research2, 157–164) – to construct an integrated, holistic conceptual model of the intention–behaviour gap of ethically minded consumers. This holistic conceptual model addresses significant limitations within the ethical consumerism literature, and moves the understanding of ethical consumer behaviour forward. Further, the operationalisation of this model offers insight and strategic direction for marketing managers attempting to bridge the intention–behaviour gap of the ethically minded consumer. (shrink)

ABSTRACTMany texts in the Epicurean tradition mention gratitude but do not explicitly explain its function in Epicurean ethics. I review passages that mention or discuss gratitude and ingratitude a...

While stakeholder theory has traditionally considered organization’s interactions with stakeholders in terms of independent, dyadic relationships, recent scholarship has pointed to the fact that organizations exist within a complex network of intertwining relationships [e.g., Rowley, T. J.: 1997, The Academy of Management Review 22(4), 887–910]. However, further theoretical and empirical development of the interactions between stakeholders has been lacking. In this paper, we develop a framework for understanding and measuring the effects upon the organization of competing, complementary and cooperative stakeholder (...) interactions, which we refer to as stakeholder multiplicity. We draw upon three forms of fit (i.e. fit as matching, fit as moderation, and fit as gestalts; Venkatraman, N.: 1989) to develop a framework for understanding stakeholder multiplicity based upon the direction, strength, and synergies of the interacting claims. Additionally, we draw upon the theory of stakeholder identification and salience of Mitchell et al. (1997), which we argue provides a more relevant and significantly more illustrative explanation of the nature and effects of stakeholder interactions upon the organization than the network approach of Rowley (1997). Furthermore, we ground our framework through reference to three stakeholder groups (i.e. governments, customers, and employees) and the stakeholder issue of concern for the natural environment. We propose a hierarchy of the multiplicity strength of influence of these three stakeholder groups. Potential measurement and implications are discussed. (shrink)

Evidential Decision Theory and Causal Decision Theory are the leading contenders as theories of rational action, but both face counterexamples. We present some new counterexamples, including one in which the optimal action is causally dominated. We also present a novel decision theory, Functional Decision Theory, which simultaneously solves both sets of counterexamples. Instead of considering which physical action of theirs would give rise to the best outcomes, FDT agents consider which output of their decision function would give rise to the (...) best outcome. This theory relies on a notion of subjunctive dependence, where multiple implementations of the same mathematical function are considered to have identical results for logical rather than causal reasons. Taking these subjunctive dependencies into account allows FDT agents to outperform CDT and EDT agents in, for example, the presence of accurate predictors. (shrink)

The present study investigated how the magnitude the word blindness suggestion effect on Stroop interference depended on hypnotic suggestibility when given as an imaginative suggestion and under conditions in which hypnosis was not mentioned. Hypnotic suggestibility is shown to be a significant predictor of the magnitude of the imaginative word blindness suggestion effect under these conditions. This is therefore the first study to show a linear relationship between the imaginative word blindness suggestion effect and hypnotic suggestibility across the whole hypnotizability (...) spectrum. The results replicate previous findings showing that highs respond to the word blindness suggestion to a greater extent than lows but extend previous work by showing that the advantage for those higher on the hypnotizability spectrum occurs even in a non-hypnotic context. Negative attitudes about hypnosis may not explain the failure to observe similar effects of the word blindness suggestion in less hypnotizable individuals. (shrink)

Some propositions are more epistemically important than others. Further, how important a proposition is is often a contingent matter—some propositions count more in some worlds than in others. Epistemic Utility Theory cannot accommodate this fact, at least not in any standard way. For EUT to be successful, legitimate measures of epistemic utility must be proper, i.e., every probability function must assign itself maximum expected utility. Once we vary the importance of propositions across worlds, however, normal measures of epistemic utility become (...) improper. I argue there isn’t any good way out for EUT. (shrink)

There are many things—call them ‘experts’—that you should defer to in forming your opinions. The trouble is, many experts are modest: they’re less than certain that they are worthy of deference. When this happens, the standard theories of deference break down: the most popular (“Reflection”-style) principles collapse to inconsistency, while their most popular (“New-Reflection”-style) variants allow you to defer to someone while regarding them as an anti-expert. We propose a middle way: deferring to someone involves preferring to make any decision (...) using their opinions instead of your own. In a slogan, deferring opinions is deferring decisions. Generalizing the proposal of Dorst (2020a), we first formulate a new principle that shows exactly how your opinions must relate to an expert’s for this to be so. We then build off the results of Levinstein (2019) and Campbell-Moore (2020) to show that this principle is also equivalent to the constraint that you must always expect the expert’s estimates to be more accurate than your own. Finally, we characterize the conditions an expert’s opinions must meet to be worthy of deference in this sense, showing how they sit naturally between the too-strong constraints of Reflection and the too-weak constraints of New Reflection. (shrink)

In this paper I hope to show that Geach misunderstands the nature of Plato's argument in the Euthyphro and more importantly the reasoning behind the dialectical strategy adopted by Socrates. Furthermore I shall argue that Geach's reading of the Euthyphro engenders serious difficulties, that stand in the way of understanding the manner in which Plato construes the problem of determining the nature of, and relationship between universal and particulars, which is of great significance because it is precisely this problem, in (...) relation to piety, that is central to the Euthyphro. In the appendix I shall sketch the outline of an argument in order to justify the assumption that the theory of Forms is present in the Euthyphro. (shrink)

These essays collectively present new perspectives on the history of modern science in China since 1900. Fa‐ti Fan describes how science under the Republic of China after 1911 exhibited a complex local and international character that straddled both imperialism and colonialism. Danian Hu focuses on the fate of relativity in the physics community in China after 1917. Zuoyue Wang hopes that a less nationalist political atmosphere in China will stimulate more transnational studies of modern science, which will in turn reveal (...) the underlying commonalities in different national contexts. Sigrid Schmalzer compares the socialist and the capitalist contexts for science in China and reopens the sensitive question of the “mass line” during the Cultural Revolution. Grace Shen describes the tensions early Chinese scientists felt when choosing between foreign models for modern geology and their own professional identities in China. Taken together, these accounts present us with a comparative history of modern science in China that is both globally and locally informed. (shrink)

© 2020, Edizioni ETS. All rights reserved. This lecture outlines elements central to the project of rethinking the concerns of political theology. The lecture seeks to integrate that thinking into the development of a philosophy of life; life defined by an already given relation to the law. Maintaining the law, which is the stance against nihilism, whilst complicating the way law is understood, involves a shift in how sovereignty would itself then be conceived.

In recent years, Plato’s Lysis has received much attention from professional scholars, but could it be used as a text in introductory classes? It is true that the Lysis poses challenges as an introductory text—its arguments are fast-paced and abstract. But I argue that the Lysis is actually an excellent pedagogical text, well suited to engage novices and introduce them to philosophy’s distinctive methods and way of thinking. It works particularly well as a text for engaging students in active learning, (...) insofar as it opens up a space for improvisation and exploration, providing tools for the readers and inviting them to take an active role in constructing their own understandings. (shrink)

In the Alcibiades I, Socrates argues for the importance of self-knowledge. Recent interpreters contend that the self-knowledge at issue here is knowledge of an impersonal and purely rational self. I argue against this interpretation and advance an alternative. First, the passages proponents of this interpretation cite—Socrates’ argument that the self is the soul, and his suggestion that Alcibiades seek self-knowledge by looking for his soul’s reflection in the soul of another—do not unambiguously support their reading. Moreover, other passages, particularly Socrates’ (...) cross-examination of Alcibiades, suggest the contrary reading, that self-knowledge includes knowledge of qualities peculiar to the individual. (shrink)

We consider the questions of whether or not large language models (LLMs) have beliefs, and, if they do, how we might measure them. First, we consider whether or not we should expect LLMs to have something like beliefs in the first place. We consider some recent arguments aiming to show that LLMs cannot have beliefs. We show that these arguments are misguided. We provide a more productive framing of questions surrounding the status of beliefs in LLMs, and highlight the empirical (...) nature of the problem. With this lesson in hand, we evaluate two existing approaches for measuring the beliefs of LLMs, one due to Azaria and Mitchell (The internal state of an llm knows when its lying, 2023) and the other to Burns et al. (Discovering latent knowledge in language models without supervision, 2022). Moving from the armchair to the desk chair, we provide empirical results that show that these methods fail to generalize in very basic ways. We then argue that, even if LLMs have beliefs, these methods are unlikely to be successful for conceptual reasons. Thus, there is still no lie-detector for LLMs. We conclude by suggesting some concrete paths for future work. (shrink)

In what follows I shall consider symbols only in their function as conveyors of meanings. That symbols have emotive and volitional properties as well, that they have elaborate and complicated relations to the self which uses them, that they are themselves physical counters, i.e., noises, visual objects, etc.,—all of these facts I recognize but choose to neglect. When symbols are considered merely as instruments for the transfer of meanings, only one important assumption is involved, viz., symbols which are precisely defined (...) are to be preferred to symbols which either are undefined or are defined inadequately. In other words, the task of a theory of meaning is that of showing how symbols take on a maximum degree of precision in significance. (shrink)

It is helpful for any enterprise to stop occasionally and examine itself. Science has done this rather infrequently in its long and eventful history, and there has not been, in general, any continuity in these self-examinations. As a result the history of the philosophy of science has been a rather spotty affair. My belief is that the philosophy of science should also, at times, become self-critical. When a study is concerned primarily with methods of other disciplines it tends to underemphasize (...) the role played by the methods which it itself uses. What is the method of the philosophy of science, and is it justifiable? Can there be a satisfactory study of science and can this be scientific? (shrink)

I suppose it is generally agreed that the task of science is to render intelligible, or in some way account for, the objects and events of our experience. Usually we say that the job of science is to explain. While this is a satisfactory formulation for most purposes, it hides a difficulty. What is meant by “explanation”? The many interpretations of this word divide scientists and philosophers of science into sharply differentiated schools. For some “explanation” means answering the question, Why?; (...) for others it means merely describing. For some it means finding causes; for others it means finding effects or abandoning entirely the search for causes and effects. For some it means employing quantitative methods only; for others it means supplementing or replacing quantitative methods by qualitative. For some it means interpreting or understanding; for others it means merely adjusting oneself in a practical way. (shrink)

The extent to which the scientific method has yielded to analysis in recent years serves only to emphasize by contrast the presence within that method of an irrational element. For it is becoming increasingly evident that whatever one may say of the logical and psychological character of the pre-inductive operations, of the formal processes involved in deducing the consequences of a given theory, of the technique of experimental corroboration, and of certain other aspects of the scientific method, there is one (...) phase of the movement which remains a surd. This is the act of the creative imagination through which hypotheses and theories are called into being. Its mysterious character is exhibited in the terminology which is employed in describing it, in the variety and inconstancy of the conditions which give rise to it, in the apparent impossibility of controlling it, and in the impossibility of recognizing completely the adequacy of its results when it does occur. It is variously described as an act of intuition, mystic revelation, divine insight, a flash of understanding; it arises out of the greatest variety of conditions: acute and prolonged attention to the data in the confinement of the laboratory, or the complete relaxation of a walk in the country, or the intense mental effort upon a problem in a wholly unrelated field; it forbids direction, in fact it seems to arise most readily when the element of effort and control is conspicuously absent; it cannot even be certainly identified, for many supposed acts of discovery prove later to have produced only groundless fancies and absurd creations of the unguided imagination. (shrink)